Environmental Genomics (Methods in Molecular Biology) by: C. Cristofre Martin

Publisher: Humana Press | 18-01-2008 | ISBN: 1588297772 | 407 pages | 3.33 Mb

Environmental genomics seeks to predict how an organism or organisms will respond, at the genetic level, to changes in their external environment. These genome responses are diverse and, as a result, environmental genomics must integrate molecular biology, physiology, toxicology, ecology, systems biology, epidemiology and population genetics into an interdisciplinary research program. Environmental Genomics serves as a manual for an environmental scientist who wishes to embrace genomics in an effort to answer environmental questions. The volume is divided into the sections: gene expression profiling, whole genome and chromosome mutation detection, and methods to assay genome diversity and polymorphisms within a particular environment. The studies presented will reduce the uncertainties associated with environmental risk assessment and provide a systematic framework for determining environmental impact and ensuring human health and the sustainability of natural populations. Environmental Genomics should aid researchers looking to reduce the uncertainties associated with environmental risk assessment and provide a systematic framework for determining environmental impact and ensuring human health and the sustainability of natural populations.

Mirror

Free Try UseNext er, 150GB ebooks, audiobooks free for 14 days!

English : Environmental Genomics (Methods in Molecular Biology) by: C. Cristofre Martin

Chinese : Environmental Genomics (Methods in Molecular Biology) by: C. Cristofre Martin

Hans Werner Müller “Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology”

Wiley-VCH | 2008-04-18 | ISBN: 3527317074 | 249 pages | PDF | 5,7 MB

With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics, glycomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases.

Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of ‘-omics’ technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation, and more. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.

FREE:

uploading.com

depositfiles.com

]]> http://www.ebookdigger.com/neural-degeneration-and-repair-gene-expression-profiling-proteomics-and-systems-biology.html/feed 0 http://www.ebookdigger.com/expression-profiling-of-human-tumors-diagnostic-and-research-applications.html http://www.ebookdigger.com/expression-profiling-of-human-tumors-diagnostic-and-research-applications.html#comments Tue, 16 Dec 2008 23:30:39 +0000 admin http://www.ebookdigger.com/expression-profiling-of-human-tumors-diagnostic-and-research-applications.html

Expression Profiling of Human Tumors: Diagnostic and Research Applications

Publisher:Humana Press

Number Of Pages:416

Publication Date:2003-05-01

Sales Rank:1834717

ISBN / ASIN:1588291227

EAN:9781588291226

Binding:Hardcover

Manufacturer:Humana Press

Studio:Humana Press

A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

English Download:Expression Profiling of Human Tumors: Diagnostic and Research Applications

Chinese Download:Expression Profiling of Human Tumors: Diagnostic and Research Applications

Publisher: Humana Press | 2007-06-05 | 217 pages | ISBN: 1588296768 | 2.43 MB | Rapidshare&MegauploadSerial Analysis of Gene Expression (SAGE): Digital Gene Expression Profiling facilitates the introduction of SAGE into the laboratory, and provides a framework for interpreting and comparing data derived from SAGE experiments. Of the several methods of genetic profiling available, only SAGE measures the expression of both known and unknown genes. SAGE studies encompass 50,000 tags and can provide detailed knowledge of the 2000 most highly expressed genes in the tissue sample.Comparative transcriptomics enables scientists to understand the underlying genetics of biological changes such as development, disease, crop yield, and resistance. SAGE analysis is also used to obtain unknown tags, which can be used as gene-specific primers in Rapid Amplification of cDNA Ends (RACE) reactions to generate full-length transcripts for cloning and sequencing. This book will be an indispensable tool for any lab engaged in genetic profiling and comparative transcriptomics, and will help many laboratories to successfully implement tag-based sequencing methods and procedures and obtain comprehensive, useful, and interpretative data. RapidshareMegaupload”Methods in Molecular Biology” Collections: ss: nguyenhuyMegaupload FoderN1

English Download:Serial Analysis of Gene Expression (SAGE): Methods and Protocols (Methods in Molecular Biology Volume 387)

Chinese Download:Serial Analysis of Gene Expression (SAGE): Methods and Protocols (Methods in Molecular Biology Volume 387)

Humana Press | 1588298906 | Edition – 2007 | PDF | 345 pages | 3.61 MB | Rapidshare & MegauploadTarget Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.Ebooks Collection: ss: nguyenhuyMegaupload FolderN1No Mirror

English Download:Target Discovery and Validation, Volume 2: Reviews and Protocols: Emerging Molecular Targets and Treatment Options (Methods in

Chinese Download:Target Discovery and Validation, Volume 2: Reviews and Protocols: Emerging Molecular Targets and Treatment Options (Methods in

Humana Press; 1 edition | ISBN: 1588292606 | 310 pages | December 23, 2004 | PDF | 6 MbExpert laboratorians noted for their optimized methods describe in step-by-step detail how to successfully carry out tissue-based laser microdissection in their own laboratory using the different systems available and to apply a wide range of sophisticated molecular technologies to the microdissected tissue samples. Highlights include gene expression profiling of primary tumor cell populations using laser capture microdissection, RNA transcript amplification and GeneChip庐 microarrays, laser capture microdissection and colorectal cancer proteomics, and proteomic analysis of human bladder tissue using SELDI庐 approach following microdissection techniques. Applications of the microdissected tissue described encompass PCR, gene expression studies including microarray analysis, and proteomics.IceFile.com

English Download:Laser Capture Microdissection: Methods and Protocols

Chinese Download:Laser Capture Microdissection: Methods and Protocols